Adaptive engineering of a hyperthermophilic archaeon on CO and discovering the underlying mechanism by multi-omics analysis

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The hyperthermophilic archaeon Thermococcus onnurineus NA1 can grow and produce H2 on carbon monoxide (CO) and its H2 production rates have been improved through metabolic engineering. In this study, we applied adaptive evolution to enhance H2 productivity. After over 150 serial transfers onto CO medium, cell density, CO consumption rate and H2 production rate increased. The underlying mechanism for those physiological changes could be explained by using multi-omics approaches including genomic, transcriptomic and epigenomic analyses. A putative transcriptional regulator was newly identified to regulate the expression levels of genes related to CO oxidation. Transcriptome analysis revealed significant changes in the transcript levels of genes belonging to the categories of transcription, translation and energy metabolism. Our study presents the first ...

Do you ever get an odd sensation over something that may seem utterly not worth such

Do you ever get an odd sensation over something that may seem utterly not worth such a feeling. You know, the goosebumps and perhaps some misty eyes. Well that happened to me today, over a piece of tech that is 30 years old. The SEGA Mega Drive brings back so many nostalgic memories, I almost fainted. But of course I’m not talking about the original 1989 version but the SEGA Mega Drive Mini that launched back in September. I was never a Nintendo or Commodore 64 man, I know those brands have launced their own mini consoles. But I couldn’t give a suff, Mario can stick his head up… Oh man I need to calm down. But seriously, as a kid we didn’t have much coin so I’d go with my late father to Video Ezy at Wyoming on the Central Coast and rent a console over a weekend. Today is the first time since , I’ve heard the familiar Sonic the Hedgegog jingles and sound effects, the same with Alex Kid in the Enchanted Castle and more. Back then the Channel 9 cricket commentary team, my next door neighbour’s love of Slim Dusty on vinyl and a tiny TV showcasing the SEGA Megadrive was my summer soundtrack. It’s actually now a little absurd to be sitting back playing the 42 in-built games on a 65-in...

Headlight Control Module Market Global Insights and Industry Outlook 2019 to 2026 By HELLA GmbH & Co. KGaA; Continental AG; Magneti Marelli S.p.A.; VALEO SERVICE; ZKW

Data Bridge Market Research Adds “Global Headlight Control Module Market – Industry Trends and Forecast to 2026” new report to its research database. The report spread No of pages: 350 No of Figures: 60 No of Tables: 220 in it. This report proves to be a useful guide for the individuals related to Headlight Control Module market as it accommodates data such as advancement patterns, competitive scene examination, and key locales improvement status. Few of the major competitors currently working in the HELLA GmbH & Co. KGaA; Continental AG; Magneti Marelli S.p.A.; VALEO SERVICE; ZKW; Renesas Electronics Corporation; Lear Corporation; HYUNDAI MOBIS; Aptiv; Robert Bosch GmbH; NXP Semiconductors; DENSO CORPORATION; KOITO MANUFACTURING CO., LTD.; Signal Dynamics; Keboda; Transtech; KEETEC; OSRAM GmbH; Texas Instruments Incorporated; Magna International Inc.; Infineon Technologies AG; Guangzhou Yaopei Auto Parts Co.,Ltd; ORACLE LIGHTING Get a Sample PDF of Headlight Control Module Report @ (Note: Kindly use your business/corporate email id to get priority): https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-headlight-control-module-market The report interfaces t...

Lanner introduces NCA-6110 2U rackmount network security appliance

November 14, 2019 – Lanner announced the launch of the NCA-6110, 2U rackmount network security appliance powered by the AMD EPYC 7000 Series CPU and offers up to 40Gbps encryption/decryption security acceleration is designed for application delivery, mobile edge computing, WAN optimization, DPI/IPS/IDS, NFV/SDN and NGFW/UTM. The NCA-6110’s specs include its support for up to 512GB DDR4 2666MHz ECCR-DIMM, dual GbE RJ45 ports, 4x or 2x 3.5” or 2.5” swappable bays, 1x RJ45 console port and 2x PCIe*8 FHHL or 1x PCIe*16 FHFL. The NCA-6110 accommodates up to eight NIC module slots that support 1/10/40/100G copper/fiber interface. These NIC module slots are compatible with Lanner’s F.A.S.T. (flexibility, adaptability, scalability and transformability) module solutions, delivering the following functionalities: November 14, 2019 – Lanner announced the launch of the NCA-6110, 2U rackmount network security appliance powered by the AMD EPYC 7000 Series CPU and offers up to 40Gbps encryption/decryption security acceleration is designed for application delivery, mobile edge computing, WAN optimization, DPI/IPS/IDS, NFV/SDN and NGFW/UTM. The NCA-6110’s specs include its support for up to 512...

Modular Fixture Plates Perfect For Small Production Runs

If you’ve ever done any small production runs of anything that needs a bit of assembly, you know that jigs and fixtures are a huge time saver. However, these usually need to be mounted, which means you end up drilling holes in your workbench or making one-off mounting plates. [Jim Smith] is no stranger to this problem, and created the Pact Plate, an affordable modular fixture plate and is running a Kickstarter campaign to get it produced. Each plate 150 mm × 150 mm in size with a 25 × 25 mm grid of holes with M4 threaded inserts. This allows quickly and easily mounted to and removed from the plate without the need to drill additional holes. Plates can be bolted together to form larger plates. The demo video shows him using a variety of 3D printed jigs, toggle clamps, PCB and part holders (available for download) and even a robot to quickly set up small assembly stations. This could also save a lot of time during the prototyping and development phases to hold parts in place. [Jim]’s prototypes are all 3D printed, but want’s to get tooling made to produce the plates using injection moulding. He doesn’t say what material he intends to use, but it’s likely some type of fibre reinfor...

Sometimes I need to be able to take photographs of very small things, and the so-called

Sometimes I need to be able to take photographs of very small things, and the so-called macro mode on my point-and-shoot camera just won’t cut it. And it never hurts to have an inspection scope on hand for tiny soldering jobs, either, though I prefer a simple jeweler’s loupe in one eye for most tasks. So I sent just over $40 off to my close friend Alibaba, and a few weeks later was the proud owner of a halfway usable inspection scope that records stills or video to an SD card. Unfortunately, it’s only halfway useable because of chintzy interface design and a wobbly mount. So I spent an afternoon, took the microscope apart, and got it under microcontroller control, complete with WiFi and a scripting language. Much better! Now I can make microscope time-lapses, but much more importantly I can take blur-free photos without touching the wiggly rig. It was a fun hack, so I thought I’d share. Read on! The scope, as it arrives, is really fun. The image is just fine and most everything works as advertised. Looking at bugs and flowers was good for a few hours at least. However, all of the small details that make for a pleasant user experience are botched. For instance, the clearance on t...

China M2201 22 Inch Narrow Bezel Desktop Computer PC Monitor, Full HD IPS Panel LCD LED Display Monitor on Global Sources

We use cookies to give you the best possible experience on our website. For more details including how to change your cookie settings, please read our Cookie Policy. Path: All Categories >> Consumer Electronics >> Computer & Laptop Accessories >> Computer Monitors >> LED PC monitors (20-inch to 22-inch) – Update me on new products View latest products We’ve sent a confirmation e-mail to XXX@gmail.com. Click on the link in the e-mail to activate and start receiving free alerts when new products are posted! - Two years warranty.- 1% spare part provided free.- OEM, ODM services are provided, provide unit and packing material with your brand. - We can send the technicians to your country to solve out the technicians problems.- You can be the sole agency at local place.- Provide CB, CE, FCC, ERP, ROHS, SASO, MEPS etc. 1. We are aiwa (Since 1951 Japan) China factory, Japan technology and quality.Factory located in Guangzhou China, factory covering more than 12000 square meters, with nearly 200 skilled workers, 7 assembly lines and module production workshop, production capacity: 7000pcs/day. 3. Our products are exported all over the world, and our cu...

The art of waterjet cutting The FABRICATOR STAMPING Journal The Welder The Tube and Pipe Journal The FABRICATOR en Español The Additive Report The FABRICATOR The Welder The Tube and Pipe Journal STAMPING Journal The Additive Report The FABRICATOR en Español

After a year of planning; designing; fabricating; and an around-the-clock, 84-hour installation, “Wake” made its debut in Times Square on July 11, 2018. (Left to right)University of North Carolina-Asheville sculpture student Jeb Hedgecock; engineering seniors Kyle Ward and Kaitlin Thomas; STEAM Studio Director Sara Sanders; and engineering seniors Brittany Hand, Zoe Rorvig, Jacob Fink, and Elijah Nonamaker comprised the installation team. Photo by Adam Taylor. You wouldn’t think a story involving conceptual art and a university-based maker space would have a lot to do with metal fabricating, but you’d be wrong in this one instance. In fact, if your shop has ever thought about expanding its cutting capabilities with a waterjet, you might want to keep reading. The story begins in 2016 when the University of North Carolina-Asheville’s engineering department was in dire need of an expanded workshop. It had only about 1,500 square feet stocked with old metalworking equipment, and the program was expanding, accommodating more students interested in the school’s mechatronics curriculum. University administrators recognized the challenge, but also saw an opportunity to address another s...