A hand-held device to predict heart failure based on saliva could help millions of potential victims take preventative steps to avoid their fate.

Nano-sensors on the tip of the diagnostic stick measure heart disease biomarkers from saliva to accurately predict the risk of heart disease, failure or heart attack, then warn users via a simple app.

Now a deal led by Melbourne-based start-up, ESN Cleer, has just been signed to bring the life-saving technology to market.

Partners, RMIT University and the Innovative Manufacturing Cooperative Research Centre (IMCRC), are researching and developing the device for pilot manufacture, with expectations it will hit market by 2021.



ESN Cleer CEO, Leopoldt de Bruin, said the collaboration represented some of the best minds in medical device innovation, design and manufacture.

We're really pleased to be able to bring these strands together in addressing such a major global health challenge.

Of the 400 million people who suffer from cardiovascular disease globally, only 16 per cent of cases are due to genetic traits. This underlines how much room there is to improve on screening and prevention, which is where this device could have such an impact."

Cardiovascular disease currently accounts for nearly one-third of all global disease deaths each year.

Research Co-Director of RMIT's Functional Materials and Microsystems Research Group, Professor Sharath Sriram, said this was the first portable heart disease test with such high levels of accuracy.

The sensing technology, developed at RMIT's cutting-edge MicroNano Research Facility, was validated in the lab to measure biomarker concentrations a thousand times more precisely than levels in human body fluids.

"Often, blood tests are only conducted after a heart failure episode. Such reactive testing is too late, leaving people with debilitating illness or leading to deaths.

"Prevention is always better than cure, which is where this technology comes in, adding accurate prediction to the mix."

The IMCRC funding, which matches contributions from ESN Cleer, is enabling a $3.5 million project investment into addressing the challenge of manufacturing and large-scale production of these diagnostic swabs.

"Utilizing advanced materials and adopting high-precision, automated manufacturing processes will allow the swabs to be high value and at a competitive cost", explained David Chuter, CEO and Managing Director at the IMCRC.

RMIT healthcare design expert Dr Leah Heiss is also on the team, bringing insights into designing the device to be as user-friendly as possible.

"The aesthetics, tactility and usability of the product has to be balanced with manufacturability and cost," Heiss said.

"By bringing users into the design process early on, we are considering the human experience in parallel with the operation of the technology."

Incentivized feedback through the system will encourage users to take preventative actions, while machine learning algorithms used to assess results will further improve system accuracy over time.

Tags: Biomarker, Blood, Body Fluids, Cancer, Cardiovascular Disease, Genetic, Healthcare, Heart, Heart Attack, Heart Disease, Heart Failure, Machine Learning, Manufacturing, Research

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